Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-[2-(6-Benzyloxy-3-methyl-1H-indol-5-yl)-2-oxo-ethyl]-piperazine-1-carboxylic acid benzyl ester → 4-[1-(6-Benzyloxy-3-methyl-1H-indole-5-carbonyl)-2-dimethylamino-vinyl]-piperazine-1-carboxylic acid benzyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-[2-(6-Benzyloxy-3-methyl-1H-indol-5-yl)-2-oxo-ethyl]-piperazine-1-carboxylic acid benzyl ester | HCID 57934816 | — |
| 용매 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 생성물 | 4-[1-(6-Benzyloxy-3-methyl-1H-indole-5-carbonyl)-2-dimethylamino-vinyl]-piperazine-1-carboxylic acid benzyl ester | HCID 69060591 | 43% |
반응 단계
A solution of 4-[2-(6-benzyloxy-3-methyl-1H-indol-5-yl)-2-oxo-ethyl]-piperazine-1-carboxylic acid benzyl ester (0.661 g, 1.33 mmol) in DMFDMA (5 ml) was heated at 100° C. overnight. The solvent was removed in vacuo and the crude product purified by column chromatography in hexane/EtOAc (1:1) to afford the product (0.158 g, 22%). LC/MS: RT=5.33 min. 553 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07612201B2 |
| 출처 데이터셋 | uspto-grants-2009_11 |
| ORD ID | ord-c1e19cc227ec484eaef68e791d199131 |
| 출처 메모 | uspto-grants-2009_11 |