4-(Trifluoromethyl)benzylamine → HCID 178506180, 화합물

HRID 1433199노트

반응식

HRID 1433199 반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7](Cl)=[N:8][C:4]=2[CH:3]=1.[F:12][C:13]([F:23])([F:22])[C:14]1[CH:21]=[CH:20][C:17]([CH2:18][NH2:19])=[CH:16][CH:15]=1>>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7]([NH:19][CH2:18][C:17]3[CH:16]=[CH:15][C:14]([C:13]([F:12])([F:22])[F:23])=[CH:21][CH:20]=3)=[N:8][C:4]=2[CH:3]=1

참가 물질

3

반응물 2

HCID 768044-(Trifluoromethyl)benzylamineHCID 178478307HCID 178478307, 화합물

생성물 1

HCID 178506180HCID 178506180, 화합물수율 63%

반응 조건

온도
200 °C

실험 절차

A mixture of 5-bromo-2-chloro-1H-benzoimidazole (0.100 g, 0.432 mmol) and 4-trifluoromethyl-benzylamine (0.8 mL) was heated in a microwave apparatus at 200° C. for 1 hour. The reaction mixture was cooled, and purified by chromatography (silica, hexanes: EtOAc, 1:1) to afford the title product as a white solid (0.101 g, 63%).

후처리

  1. temperatureThe reaction mixture was cooled
  2. custompurified by chromatography (silica, hexanes: EtOAc, 1:1)

출처 및 근거

ORD 기록
ord-218d1f6dcce94105887ebbd8e7d09988
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612211B2

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