참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Nitrophenol | HCID 980 | — |
| 반응물 | 2,6-Lutidine | HCID 7937 | — |
| 반응물 | 4-Chloro-6-cyano-7-(2-methoxyethoxy)quinoline | HCID 22646522 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 6-Cyano-7-(2-methoxyethoxy)-4-(4-nitrophenoxy)quinoline | HCID 22936341 | 43.1% |
반응 단계
A mixture of 4-chloro-6-cyano-7-(2-methoxyethoxy)quinoline (3 g), 4-nitrophenol (3.17 g) and 2,6-lutidine (2.7 ml) was heated and stirred in an oil bath at 155° C. for 1.5 hours. After completion of the reaction, ethyl acetate was added, and the precipitated solid was filtered out. The solid was washed with 1N sodium hydroxide water and then with water and dried to obtain 1.8 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07612092B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_11 |
|---|
| ORD ID | ord-05cf31fa4a5e4d76aac9fd704d970649 |
|---|
| 출처 메모 | uspto-grants-2009_11 |
|---|
