Glycidyl tosylate, (R)- → HCID 58931216, 화합물

반응식

[CH2:1]([NH:3][C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[OH:16])[N:12]=[CH:11][CH:10]=[C:9]2[O:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][C:25]([NH:27][CH:28]2[CH2:30][CH2:29]2)=[O:26])=[C:20]([Cl:31])[CH:19]=1)=[O:5])[CH3:2].CC1C=CC(S(O[CH2:43][C@H:44]2[CH2:46][O:45]2)(=O)=O)=CC=1>>[CH2:1]([NH:3][C:4]([C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[O:16][CH2:43][C@H:44]1[CH2:46][O:45]1)[N:12]=[CH:11][CH:10]=[C:9]2[O:17][C:18]1[CH:23]=[CH:22][C:21]([NH:24][C:25]([NH:27][CH:28]2[CH2:30][CH2:29]2)=[O:26])=[C:20]([Cl:31])[CH:19]=1)=[O:5])[CH3:2]

참가 물질

반응물 2

HCID 154187Glycidyl tosylate, (R)-

HCID 135829404HCID 135829404, 화합물

생성물 1

HCID 58931216HCID 58931216, 화합물수율 47.4%

실험 절차

The title compound (235.4 mg, 0.474 mmol, 47.4%) was obtained as light yellow crystals from N6-ethyl-4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)-7-hydroxy-6-quinolinecarboxamide) (440.9 mg, 1.00 mmol) and (2R)oxiran-2-ylmethyl 4-methyl-1-benzenesulfonate, by the same procedure as in Example 7.

출처 및 근거

ORD 기록: ord-2243c05d78c0448eb1bd74f96fd0678c
출처 데이터셋: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07612092B2

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