(2S,3R)-3-(benzyloxy)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid → (R)-tert-Butoxycarbonylamino-[4-(2-methoxy-ethoxy)-phenyl]-acetic acid

HRID 1433779

반응식

HRID 1433779 반응식
C(O[C@H](C)[C@H](NC(OCC1C2C=CC=CC=2C2C1=CC=CC=2)=O)C(O)=O)C1C=CC=CC=1.[C:33]([O:37][C:38]([NH:40][C@H:41]([C:45]1[CH:50]=[CH:49][C:48]([O:51][CH2:52][CH2:53][O:54][CH:55]2CCCCO2)=[CH:47][CH:46]=1)[C:42]([OH:44])=[O:43])=[O:39])([CH3:36])([CH3:35])[CH3:34].C(OC(N[C@H](C1C=CC(OCC(OC)OCC)=CC=1)C(O)=O)=O)(C)(C)C.C(OC(NC(C1C=CC(OCCOC)=CC=1)C(O)=O)=O)(C)(C)C>>[C:33]([O:37][C:38]([NH:40][C@H:41]([C:45]1[CH:46]=[CH:47][C:48]([O:51][CH2:52][CH2:53][O:54][CH3:55])=[CH:49][CH:50]=1)[C:42]([OH:44])=[O:43])=[O:39])([CH3:36])([CH3:35])[CH3:34]

참가 물질

5

반응물 4

HCID 16213170(2S,3R)-3-(benzyloxy)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acidHCID 66815176Tert-butoxycarbonylamino-[4-(2-methoxy-ethoxy)-phenyl]-acetic acidHCID 68617730(R)-tert-butoxycarbonylamino-{4-[2-(tetrahydropyran-2-yloxy)-ethoxy]-phenyl}-acetic acidHCID 131727731(R)-tert-butoxycarbonylamino-[4-(methoxy-ethoxy-ethoxy)-phenyl]-acetic acid

생성물 1

HCID 66815175(R)-tert-Butoxycarbonylamino-[4-(2-methoxy-ethoxy)-phenyl]-acetic acid

실험 절차

Prepared by the same method as described in example 3 except that (i) 2-chloro-4-iodo-aniline was used in place of 4-bromo-2-chloro-aniline in step 1, (ii) (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid was used in place of (S,S)-2-tert-butoxycarbonylamino-3-phenyl-butyric acid in step 1, and (iii) R)-tert-butoxycarbonylamino-[4-(2-methoxy-ethoxy)-phenyl]-acetic acid was used in place of (R)-tert-butoxycarbonylamino-[4-(2-tert-butoxy-ethoxy)-phenyl]-acetic acid in step 2. (R)-tert-butoxycarbonylamino-[4-(2-methoxy-ethoxy)-phenyl]-acetic acid was prepared as described in example 80.

후처리

  1. customPrepared by the same method

출처 및 근거

ORD 기록
ord-ff5e17e1a464433890d9c505959ab9c1
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612212B2

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