(R)-1,2-Epoxypropane → (R)-tert-Butoxycarbonylamino-[4-((R)-2-hydroxy-propoxy)-phenyl]-acetic acid

HRID 1433782

반응식

HRID 1433782 반응식
[CH2:1]([O:8][C@H](C)[C@H](NC(OCC1C2C=CC=CC=2C2C1=CC=CC=2)=O)C(O)=O)[C:2]1C=CC=CC=1.[C:33]([O:37][C:38]([NH:40][C@H:41]([C:45]1[CH:50]=[CH:49][C:48]([O:51][CH2:52]COC2CCCCO2)=[CH:47][CH:46]=1)[C:42]([OH:44])=[O:43])=[O:39])([CH3:36])([CH3:35])[CH3:34].C[C@@H]1CO1>>[C:33]([O:37][C:38]([NH:40][C@H:41]([C:45]1[CH:46]=[CH:47][C:48]([O:51][CH2:52][C@H:1]([OH:8])[CH3:2])=[CH:49][CH:50]=1)[C:42]([OH:44])=[O:43])=[O:39])([CH3:34])([CH3:35])[CH3:36]

참가 물질

4

반응물 3

HCID 146261(R)-1,2-EpoxypropaneHCID 16213170(2S,3R)-3-(benzyloxy)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acidHCID 68617730(R)-tert-butoxycarbonylamino-{4-[2-(tetrahydropyran-2-yloxy)-ethoxy]-phenyl}-acetic acid

생성물 1

HCID 68620103(R)-tert-Butoxycarbonylamino-[4-((R)-2-hydroxy-propoxy)-phenyl]-acetic acid

실험 절차

Prepared by the same method as described in example 3 except that (i) 2-chloro-4-iodo-aniline was used in place of 4-bromo-2-chloro-aniline in step 1, and (ii) (R)-tert-butoxycarbonylamino-[4-((R)-2-hydroxy-propoxy)-phenyl]-acetic acid was used in place of (R)-tert-butoxycarbonylamino-[4-(2-tert-butoxy-ethoxy)-phenyl]-acetic acid in step 2. (R)-tert-Butoxycarbonylamino-[4-((R)-2-hydroxy-propoxy)-phenyl]-acetic acid was prepared as described in example 48 except that (R)-2-methyl-oxirane was used in place of 2-(2bromo-ethoxy)-tetrahydropyran.

후처리

  1. customPrepared by the same method

출처 및 근거

ORD 기록
ord-9f20a8e1752c467da7840a1225c65731
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612212B2

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