(2S,3R)-3-(benzyloxy)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid → (S)-N-(2-Chloro-4-iodo-phenyl)-2-[(R)-4-(4-cyclopropylmethoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-methyl-butyramide

HRID 1433787

반응식

HRID 1433787 반응식
C(O[C@H](C)[C@H](NC(OC[CH:19]1[C:31]2C=CC=C[C:26]=2C2C1=CC=CC=2)=O)C(O)=O)C1C=CC=CC=1.[NH2:33][C@H:34]([C:58]1[CH:63]=[CH:62][C:61]([O:64][CH2:65][C@H](O)CO)=[CH:60][CH:59]=1)[C:35]([NH:37][C@@H:38]([C@H:50]([C:52]1C=CC=CC=1)[CH3:51])[C:39]([NH:41][C:42]1[CH:47]=[CH:46][C:45]([I:48])=[CH:44][C:43]=1[Cl:49])=[O:40])=[O:36].[C:70]([O:74]C(N[C@H](C1C=CC(OC[C@H]2COC(C)(C)O2)=CC=1)C(O)=O)=O)(C)(C)C>>[Cl:49][C:43]1[CH:44]=[C:45]([I:48])[CH:46]=[CH:47][C:42]=1[NH:41][C:39](=[O:40])[C@@H:38]([N:37]1[C:35](=[O:36])[C@@H:34]([C:58]2[CH:59]=[CH:60][C:61]([O:64][CH2:65][CH:19]3[CH2:26][CH2:31]3)=[CH:62][CH:63]=2)[NH:33][C:70]1=[O:74])[CH:50]([CH3:52])[CH3:51]

참가 물질

4

반응물 3

HCID 16213170(2S,3R)-3-(benzyloxy)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acidHCID 67001404(R)-tert-Butoxycarbonylamino-[4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-phenyl]-acetic acidHCID 69006543(2S,3S)-2-{(R)-2-amino-2-[4-((R)-2,3-dihydroxy-propoxy)-phenyl]-acetylamino}-N-(2-chloro-4-iodo-phenyl)-3-phenyl-butyramide

생성물 1

HCID 57935190(S)-N-(2-Chloro-4-iodo-phenyl)-2-[(R)-4-(4-cyclopropylmethoxy-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-methyl-butyramide

실험 절차

Prepared by the same method as described in example 3 except that (i) 2-chloro-4-iodo-aniline was used in place of 4-bromo-2-chloro-aniline in step 1, (ii) (S)-2-tert-butoxycarbonylamino-3-methyl-butyric acid was used in place of (S,S)-2-tert-butoxycarbonylamino-3-phenyl-butyric acid in step 1, and (iii) (R)-tert-butoxycarbonylamino-(4-cyclopropylmethoxy-phenyl)-acetic acid (prepared as described in example 109) was used in place of (R)-tert-butoxycarbonylamino-[4-(2-tert-butoxy-ethoxy)-phenyl]-acetic acid in step 2.

후처리

  1. customPrepared by the same method

출처 및 근거

ORD 기록
ord-f987c67e83fc44d683a9e83891cbbe72
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612212B2

연결된 노트

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