4-Piperidinol, 1-methyl- → HCID 23087228, 화합물

HRID 1433817노트

반응식

HRID 1433817 반응식
[OH:1]C1CCN(C)CC1.FC1C=C(C=CC=1F)C#N.[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[C:23]#N>>[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[CH:23]=[O:1]

참가 물질

4

반응물 3

HCID 660484-Piperidinol, 1-methyl-HCID 5872033,4-DifluorobenzonitrileHCID 230874123-Fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile

생성물 1

HCID 23087228HCID 23087228, 화합물

실험 절차

Synthesized from 4-hydroxy-1-methylpiperidine and 3,4-difluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 3-fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile (1.1 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (1.1 g).

후처리

  1. customwas used according to an analogous synthetic method to Preparation Example 16

출처 및 근거

ORD 기록
ord-230cd4b996c84e2fbb2af1b06b21455e
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612114B2

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