Benzene, 4-bromo-1,2-dimethoxy- → 7-Benzyloxy-3-(4,5-dimethoxy-2-nitrophenyl)-1,2-dihydronaphthalene

HRID 1433933

반응식

HRID 1433933 반응식
BrC1C=CC(OC)=C(OC)C=1.Br[C:13]1[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:14]=1[N+:23]([O-:25])=[O:24].[CH2:26]([O:33][C:34]1[CH:43]=[C:42]2[C:37]([CH:38]=[C:39](Br)[CH2:40][CH2:41]2)=[CH:36][CH:35]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:26]([O:33][C:34]1[CH:43]=[C:42]2[C:37]([CH:38]=[C:39]([C:13]3[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:14]=3[N+:23]([O-:25])=[O:24])[CH2:40][CH2:41]2)=[CH:36][CH:35]=1)[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

참가 물질

4

반응물 3

HCID 76114Benzene, 4-bromo-1,2-dimethoxy-HCID 1709684-Bromo-5-nitroveratroleHCID 230874203-Bromo-1,2-dihydro-7-(phenylmethoxy)naphthalene

생성물 1

HCID 230874267-Benzyloxy-3-(4,5-dimethoxy-2-nitrophenyl)-1,2-dihydronaphthalene수율 21.8%

실험 절차

Synthesized from 1-bromo-3,4-dimethoxybenzene according to an analogous synthetic method to Preparation Example 108, 1-bromo-4,5-dimethoxy-2-nitrobenzene (7.5 g) and 7-benzyloxy-3-bromo-1,2-dihydronaphthalene (4.5 g) were used according to an analogous synthetic method to Preparation Example 107 to provide 7-benzyloxy-3-(4,5-dimethoxy-2-nitrophenyl)-1,2-dihydronaphthalene (1.3 g). The total amount of this compound was used according to an analogous synthetic method to Example 30 to provide the title compound (822 mg).

후처리

  1. customwere used according to an analogous synthetic method to Preparation Example 107

출처 및 근거

ORD 기록
ord-c1bd0f8be5354add8b27466babec199f
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612114B2

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