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1-(2-Chloroethyl)pyrrolidine hydrochloride → 6-{2-{Cyclopropylmethyl {2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]ethyl}amino}-4-hydroxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

HRID 1434157
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인쇄 미리보기

반응식

HRID 1434157 반응식
C1(CN(C2C=C(OC)C=CC=2C2CCC3C(=CC=C(OC)C=3)C2)CCC2C=CC(O)=CC=2)CC1.Cl.ClCCN1CCCC1.[CH:44]1([CH2:47][N:48]([C:65]2[CH:70]=[C:69]([O:71]C)[CH:68]=[CH:67][C:66]=2[CH:73]2[CH2:82][CH2:81][C:80]3[C:75](=[CH:76][CH:77]=[C:78]([O:83]C)[CH:79]=3)[CH2:74]2)[CH2:49][CH2:50][C:51]2[CH:56]=[CH:55][C:54]([O:57][CH2:58][CH2:59][N:60]3[CH2:64][CH2:63][CH2:62][CH2:61]3)=[CH:53][CH:52]=2)[CH2:46][CH2:45]1>>[CH:44]1([CH2:47][N:48]([CH2:49][CH2:50][C:51]2[CH:56]=[CH:55][C:54]([O:57][CH2:58][CH2:59][N:60]3[CH2:64][CH2:63][CH2:62][CH2:61]3)=[CH:53][CH:52]=2)[C:65]2[CH:70]=[C:69]([OH:71])[CH:68]=[CH:67][C:66]=2[CH:73]2[CH2:82][CH2:81][C:80]3[CH:79]=[C:78]([OH:83])[CH:77]=[CH:76][C:75]=3[CH2:74]2)[CH2:45][CH2:46]1
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

4

반응물 3

HCID 816681-(2-Chloroethyl)pyrrolidine hydrochlorideHCID 230875484-{2-{Cyclopropylmethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amino}ethyl}phenolHCID 66626515Cyclopropylmethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]{2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]ethyl}amine

생성물 1

HCID 579344076-{2-{Cyclopropylmethyl {2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]ethyl}amino}-4-hydroxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
수율 89.4%

실험 절차

Synthesized from 4-{2-{cyclopropylmethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amino}ethyl}phenol and 1-(2-chloroethyl)pyrrolidine hydrochloride according to an analogous synthetic method to Preparation Example 40, cyclopropylmethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]{2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]ethyl}amine (284 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (241 mg).

출처 및 근거

ORD 기록
ord-e9cf5a962ed64c678b60c97d011dea7f
출처 데이터셋
uspto-grants-2009_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07612114B2

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