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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1434289생성일: 2026년 10월 27일

2-chloro-N-cyclopropylacetamide → 6-{2-{[4-(2-Cyclopropylaminoethoxy)-3-fluorobenzyl]isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

https://huagongshe.com/reaction/1434289

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참여 물질

역할이름HCID투입량
반응물2-chloro-N-cyclopropylacetamideHCID 735780—
반응물Pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl esterHCID 57934527—
생성물6-{2-{[4-(2-Cyclopropylaminoethoxy)-3-fluorobenzyl]isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-olHCID 5793431239.6%

반응 단계

Synthesized from pivalic acid 6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (26 mg) and 2-chloro-N-cyclopropylacetamide (13 mg) according to an analogous synthetic method to Example 567 and purified by LC-MS, the title compound (10 mg) was obtained.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07612114B2
출처 데이터셋uspto-grants-2009_11
ORD IDord-595e027399104642a048e1efc115c052
출처 메모uspto-grants-2009_11