Trifluoroacetic acid → L-Glutamic Acid

HRID 1434503

반응식

[NH2:1][C@H:2]([C:12]([O:14]C(C)(C)C)=[O:13])[CH2:3][CH2:4][C:5](=[O:11])[O:6]C(C)(C)C.C(ON1C(=O)CCC1=O)(=O)CCCCCCCCCCCCCCC([O-])=O.[B-](F)(F)(F)F.CN(C(ON1C(=O)CCC1=O)=[N+](C)C)C.C(O)(C(F)(F)F)=O>>[NH2:1][C@H:2]([C:12]([OH:14])=[O:13])[CH2:3][CH2:4][C:5](=[O:6])[OH:11]

참가 물질

반응물 4

HCID 6422Trifluoroacetic acid

HCID 208637L-Glutamic acid di-tert-butyl ester

HCID 98575222-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborate

HCID 131727748Succinimidyl hexadecandioate

생성물 1

HCID 33032L-Glutamic Acid

실험 절차

This compound was prepared in analogy with example 4, via reaction of L-Glu(OtBu)-OtBu with succinimidyl hexadecandioate followed by activation with TSTU, coupling with Des(B30) human insulin and deprotection by TFA. LCMS 6130.8, calculated 6132.2.

출처 및 근거

ORD 기록: ord-d1837f8ca0c74a208a5d17b723bb0257
출처 데이터셋: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07615532B2

연결된 노트

불러오는 중…