Ammonium Chloride → 4-amino-2,3-dihydro-1H-inden-2-yl acetate

HRID 1434559

반응식

HRID 1434559 반응식
[C:1]([O:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[N+:14]([O-])=O)[CH2:6]1)(=[O:3])[CH3:2].[Cl-].[NH4+]>C(O)C.O.C(OC(=O)C)C.[Fe]>[C:1]([O:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:14])[CH2:6]1)(=[O:3])[CH3:2]

참가 물질

7

반응물 2

HCID 25517Ammonium ChlorideHCID 132395834-nitro-2,3-dihydro-1H-inden-2-yl acetate

생성물 1

HCID 132395844-amino-2,3-dihydro-1H-inden-2-yl acetate

시약·촉매·용매 4

HCID 23925Iron촉매HCID 702Ethanol용매HCID 962Water용매HCID 8857Ethyl Acetate용매

반응 조건

온도
90 °C

실험 절차

To a mixture of 4-nitro-2,3-dihydro-1H-inden-2-yl acetate (100 mg, 0.45 mmol) and ammonium chloride (100 mg) in ethanol (6 ml) and water (3 ml) was added iron powder (300 mg) portionwise at room temperature. The mixture was stirred at 90° C. for 1 hour, and after cooled to room temperature, the mixture was diluted with ethylacetate. The mixture was filtered through a pad of celite, and the filtrate was washed with brine, dried over MgSO4, filtered, and concentrated under reduced pressure to obtain 4-amino-2,3-dihydro-1H-inden-2-yl acetate.

후처리

  1. temperatureafter cooled to room temperature
  2. filtrationThe mixture was filtered through a pad of celite
  3. washthe filtrate was washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-57ffff16dce048048ddc75e42ca245dc
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07615557B2

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