Triethylamine → 1-[1-(3-chloro-3-phenylpropyl)piperidin-4-yl]-5-(methylsulfonyl)-1H-benzimidazole

HRID 1434592노트

반응식

HRID 1434592 반응식
CS([Cl:5])(=O)=O.[CH3:6][S:7]([C:10]1[CH:34]=[CH:33][C:13]2[N:14]([CH:17]3[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH:25]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)O)[CH2:19][CH2:18]3)[CH:15]=[N:16][C:12]=2[CH:11]=1)(=[O:9])=[O:8].C(N(CC)CC)C>ClCCl>[Cl:5][CH:25]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:24][CH2:23][N:20]1[CH2:21][CH2:22][CH:17]([N:14]2[C:13]3[CH:33]=[CH:34][C:10]([S:7]([CH3:6])(=[O:9])=[O:8])=[CH:11][C:12]=3[N:16]=[CH:15]2)[CH2:18][CH2:19]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 68704632HCID 68704632, 화합물

생성물 1

HCID 579360111-[1-(3-chloro-3-phenylpropyl)piperidin-4-yl]-5-(methylsulfonyl)-1H-benzimidazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Methanesulphonyl chloride (0.46 ml) was added to a solution of 3-{4-[5-(methylsulfonyl)-1H-benzimidazol-1-yl]piperidin-1-yl}-1-phenylpropan-1-ol (2.1 g) and triethylamine (0.9 ml) in dichloromethane (30 ml) at 0° C. The mixture was allowed to warm to room temperature and stirring was continued for 16 hours. The reaction mixture was washed with water (15 ml) and brine (15 ml) and dried. Removal of the solvent gave the title compound as an orange foam, yield 1.85 g, M+H 432.

후처리

  1. washThe reaction mixture was washed with water (15 ml) and brine (15 ml)
  2. customdried
  3. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-bcbab8cc4ebf4c97bbb1eab318b4c20c
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07615555B2

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