Potassium Carbonate → HCID 57935976, 화합물

HRID 1434593노트

반응식

HRID 1434593 반응식
Cl[CH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[CH3:12][S:13]([C:16]1[CH:30]=[CH:29][C:19]2[N:20]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[CH:21]=[N:22][C:18]=2[CH:17]=1)(=[O:15])=[O:14].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:12][S:13]([C:16]1[CH:30]=[CH:29][C:19]2[N:20]([CH:23]3[CH2:24][CH2:25][N:26]([CH2:2][CH2:3][C:4]([C:6]4[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=4)=[O:5])[CH2:27][CH2:28]3)[CH:21]=[N:22][C:18]=2[CH:17]=1)(=[O:15])=[O:14]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 702953-ChloropropiophenoneHCID 58998518HCID 58998518, 화합물

생성물 1

HCID 57935976HCID 57935976, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

3-Chloropropiophenone (860 mg) was added to a mixture of 5-(methylsulfonyl)-1-piperidin-4-yl-1H-benzimidazole (1.395 g) and potassium carbonate (1.38 g) in DMF (30 ml) and stirred for 2 days. The reaction mixture was evaporated to dryness and the residue was dissolved in dichloromethane (20 ml), washed with water (15 ml) and brine (15 ml), dried and evaporated to dryness to give the title compound, yield 2.07 g, M+H 412, NMR (CDCl3) 2.2 (m, 4H) 2.3-2.4 (m, 2H) 2.9 (m, 2H) 3.1 (s, 3H) 3.2-3.3 (m, 4H) 4.3 (m, 1H) 7.5 (m, 2H) 7.6 (m, 2H) 7.9 (m, 2H) 8.0 (m, 1H) 8.2 (s, 1H) 8.4 (s, 1H).

후처리

  1. customThe reaction mixture was evaporated to dryness
  2. dissolutionthe residue was dissolved in dichloromethane (20 ml)
  3. washwashed with water (15 ml) and brine (15 ml)
  4. customdried
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-7fb6528ba5244589b175c6f75cd62349
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07615555B2

반응 노트

불러오는 중…