Tetrahydrofuran → 4-(2-bromo-acetyl)-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide

HRID 1434683노트

반응식

HRID 1434683 반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][C:14]2[S:15][CH:16]=[CH:17][N:18]=2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br-:19].[Br-].[Br-].[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.C1[CH2:44][O:43][CH2:42]C1>O>[Br:19][CH2:2][C:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]([CH2:42][O:43][CH3:44])[C:14]2[S:15][CH:16]=[CH:17][N:18]=2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)=[O:3]

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 210825294-Acetyl-n-(thiazol-2-yl)benzenesulfonamideHCID 21124087Pyridiniumtribromide

생성물 1

HCID 866116974-(2-bromo-acetyl)-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 4-acetyl-N-thiazol-2-yl-benzenesulfonamide (10 mmol) in THF (50 mL) was added pyridinium tribromide (10 mmol), and the mixture was stirred for 4 h. The reaction mixture was diluted with water (30 mL) and the resulting mixture was extracted with ethyl acetate. The organic phase was washed with brine, dried over MgSO4, and concentrated in vacuo. The crude product was purified by column chromatography to give 4-(2-bromo-acetyl)-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide (8.2 mmol) as a white solid.

후처리

  1. extractionthe resulting mixture was extracted with ethyl acetate
  2. washThe organic phase was washed with brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo
  5. customThe crude product was purified by column chromatography

출처 및 근거

ORD 기록
ord-182a8cebbf694424bd1e4f6844073fed
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07615569B2

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