2,6-Dichlorophenylacetamidine → 4-[2-(2,6-dichloro-benzyl)-3H-imidazol-4-yl]-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide

HRID 1434684노트

반응식

HRID 1434684 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([N:14]([CH2:20][O:21][CH3:22])[C:15]2[S:16][CH:17]=[CH:18][N:19]=2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)=O.[Cl:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:25]=1[CH2:31][C:32]([NH2:34])=[NH:33]>CN(C=O)C>[Cl:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:25]=1[CH2:31][C:32]1[NH:33][C:3]([C:5]2[CH:10]=[CH:9][C:8]([S:11]([N:14]([CH2:20][O:21][CH3:22])[C:15]3[S:16][CH:17]=[CH:18][N:19]=3)(=[O:13])=[O:12])=[CH:7][CH:6]=2)=[CH:2][N:34]=1

참가 물질

4

반응물 2

HCID 5973572,6-DichlorophenylacetamidineHCID 866116974-(2-bromo-acetyl)-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide

생성물 1

HCID 670014624-[2-(2,6-dichloro-benzyl)-3H-imidazol-4-yl]-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide수율 4.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 4-(2-bromo-acetyl)-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide (0.062 mmol) and the free base of 2-(2,6-dichloro-phenyl)-acetamidine (0.062 mmol) in DMF (2 mL) was heated to 80° C. for 2 h. After cooling to room temperature, the reaction mixture was purified by reverse phase chromatography to yield 4-[2-(2,6-dichloro-benzyl)-3H-imidazol-4-yl]-N-methoxymethyl-N-thiazol-2-yl-benzenesulfonamide (0.003 mmol).

후처리

  1. customthe reaction mixture was purified by reverse phase chromatography

출처 및 근거

ORD 기록
ord-581c1a95c1a94476bf6f55b0a6eb1715
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07615569B2

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