N,N-Dimethylethylenediamine → 2-{[2-(2-dimethylamino-ethylamino)-pyridin-4-ylmethyl]-amino}-N-(3-trifluoromethyl-phenyl)-benzamide

HRID 1434695노트

반응식

HRID 1434695 반응식
Br[C:2]1[CH:7]=[C:6]([CH2:8][NH:9][C:10]2[CH:28]=[CH:27][CH:26]=[CH:25][C:11]=2[C:12]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)=[O:13])[CH:5]=[CH:4][N:3]=1.[CH3:29][N:30]([CH2:32][CH2:33][NH2:34])[CH3:31]>N1C=CC=CC=1>[CH3:29][N:30]([CH3:31])[CH2:32][CH2:33][NH:34][C:2]1[CH:7]=[C:6]([CH2:8][NH:9][C:10]2[CH:28]=[CH:27][CH:26]=[CH:25][C:11]=2[C:12]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:23])([F:24])[F:22])[CH:16]=2)=[O:13])[CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 66053N,N-DimethylethylenediamineHCID 103437292-[(2-bromo-pyridin-4-ylmethyl)-amino]-N-(3-trifluoromethyl-phenyl)-benzamide

생성물 1

HCID 100042672-{[2-(2-dimethylamino-ethylamino)-pyridin-4-ylmethyl]-amino}-N-(3-trifluoromethyl-phenyl)-benzamide

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
200 °C

실험 절차

90 mg (0.2 mmol) of 2-[(2-bromo-pyridin-4-ylmethyl)-amino]-N-(3-trifluoromethyl-phenyl)-benzamide is dissolved in 3 ml of pyridine and mixed with 1 ml of N,N-dimethyl-aminoethylamine and heated in a pressure vessel for 5 hours to a bath temperature of 200° C. After cooling, it is concentrated by evaporation, and 90 mg of 2-{[2-(2-dimethylamino-ethylamino)-pyridin-4-ylmethyl]-amino}-N-(3-trifluoromethyl-phenyl)-benzamide is obtained.

후처리

  1. temperatureAfter cooling
  2. concentrationit is concentrated by evaporation

출처 및 근거

ORD 기록
ord-f4974aa827db412188eeb59eea5d4476
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07615565B2

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