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Ethanol → 2-(2-t-Butoxycarbonylaminoethoxy)-4-methylsulfonylbenzoic acid

HRID 1434832
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HRID 1434832 반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:21]=[C:20]([S:22]([CH3:25])(=[O:24])=[O:23])[CH:19]=[CH:18][C:13]=1[C:14]([O:16]C)=[O:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].CCO.[OH-].[K+]>O>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:21]=[C:20]([S:22]([CH3:25])(=[O:24])=[O:23])[CH:19]=[CH:18][C:13]=1[C:14]([OH:16])=[O:15])=[O:7])([CH3:4])([CH3:3])[CH3:2]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 57936591Methyl 2-(2-t-butoxycarbonylaminoethoxy)-4-methylsulfonylbenzoate

생성물 1

HCID 579366282-(2-t-Butoxycarbonylaminoethoxy)-4-methylsulfonylbenzoic acid수율 91%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

A mixture of methyl 2-(2-t-butoxycarbonylaminoethoxy)-4-methylsulfonylbenzoate (8.6 g, 23 mmol), EtOH (200 mL), and KOH (6.5 g, 115 mmol) in water (200 mL) was heated to 70° C. for 4 hours. The EtOH was removed in vacuo and the residue was diluted with CH2Cl2. The mixture was acidified with satd citric acid and partitioned. The organic layer was dried (Na2SO4) and concentrated to give the desired product as a solid (7.5 g, 91%).

후처리

  1. customThe EtOH was removed in vacuo
  2. additionthe residue was diluted with CH2Cl2
  3. custompartitioned
  4. dry with materialThe organic layer was dried (Na2SO4)
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e6fb5d921bbf4bc28182b548880eb9fa
출처 데이터셋
uspto-grants-2009_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07615568B2

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