Pyrimidine, 2,4-dichloro-5-methyl- → 4-[5-(2-Chloro-5-methyl-pyrimidin-4-yl)-thiophen-2-yl]-butyric acid methyl ester

HRID 1434925

반응식

HRID 1434925 반응식
[CH3:1][O:2][C:3](=[O:12])[CH2:4][CH2:5][CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1.[Cl:13][C:14]1[N:19]=[C:18](Cl)[C:17]([CH3:21])=[CH:16][N:15]=1>>[CH3:1][O:2][C:3](=[O:12])[CH2:4][CH2:5][CH2:6][C:7]1[S:8][C:9]([C:16]2[C:17]([CH3:21])=[CH:18][N:19]=[C:14]([Cl:13])[N:15]=2)=[CH:10][CH:11]=1

참가 물질

3

반응물 2

HCID 74508Pyrimidine, 2,4-dichloro-5-methyl-HCID 1407664-(2-Thienyl)butanoic acid methyl ester

생성물 1

HCID 579363064-[5-(2-Chloro-5-methyl-pyrimidin-4-yl)-thiophen-2-yl]-butyric acid methyl ester수율 12%

실험 절차

4-[5-(2-Chloro-5-methyl-pyrimidin-4-yl)-thiophen-2-yl]-butyric acid methyl ester was prepared analogous to Step B of Method A, starting from 4-thiophen-2-yl-butyric acid methyl ester and 2,4-dichloro-5-methyl-pyrimidine. Yield: 12%.

출처 및 근거

ORD 기록
ord-c5a93e50418242fd91a2579668c4ca5f
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07615562B2

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