4-Amino-2,2,6,6-tetramethylpiperidine → 1-{5-[2-(2,2,6,6-Tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-thiophen-2-yl}-propan-2-ol
반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH:7]([OH:9])[CH3:8].Cl[C:11]1[N:16]=[C:15](Cl)[CH:14]=[CH:13][N:12]=1.[CH3:18][C:19]1([CH3:28])[CH2:24][CH:23]([NH2:25])[CH2:22][C:21]([CH3:27])([CH3:26])[NH:20]1>>[CH3:18][C:19]1([CH3:28])[CH2:24][CH:23]([NH:25][C:11]2[N:16]=[C:15]([C:5]3[S:1][C:2]([CH2:6][CH:7]([OH:9])[CH3:8])=[CH:3][CH:4]=3)[CH:14]=[CH:13][N:12]=2)[CH2:22][C:21]([CH3:27])([CH3:26])[NH:20]1참가 물질
4
실험 절차
The title compound was prepared analogous to Steps B and C of Method A, starting from 1-thiophen-2-yl-propan-2-ol, 2,4-dichloro-pyrimidine and 2,2,6,6-tetramethyl-piperidin-4-ylamine.
출처 및 근거
- ORD 기록
- ord-678e9124b051460ca67d63b33091c19c