HCID 57936130, 화합물 → HCID 57936183, 화합물

HRID 1434992노트

반응식

HRID 1434992 반응식
[NH2:1][C:2]([CH3:29])([CH3:28])[C:3]#[C:4][C:5]1[N:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]3[CH2:23][C:22]([CH3:25])([CH3:24])[NH:21][C:20]([CH3:27])([CH3:26])[CH2:19]3)[N:12]=2)=[CH:7][CH:6]=1>CCO.[Pd]>[NH2:1][C:2]([CH3:29])([CH3:28])[CH2:3][CH2:4][C:5]1[N:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]3[CH2:23][C:22]([CH3:25])([CH3:24])[NH:21][C:20]([CH3:27])([CH3:26])[CH2:19]3)[N:12]=2)=[CH:7][CH:6]=1

참가 물질

4

반응물 1

HCID 57936130HCID 57936130, 화합물

생성물 1

HCID 57936183HCID 57936183, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

{4-[6-(3-Amino-3-methyl-but-1-ynyl)-pyridin-3-yl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine (105 mg, 0.25 mmol) was dissolved in EtOH (100 ml) and hydrogenated at 1 atm over Pd/C (10%, 105 mg) for 2 hours at room temperature. The reaction mixture was filtered, evaporated, taken up in TBME/MeOH/ammonia (90/9/1) and passed through a bed of silicagel to give the title compound as slightly yellowish crystals, crystallized from ether. Yield: 35 mg (33%).

후처리

  1. filtrationThe reaction mixture was filtered
  2. customevaporated

출처 및 근거

ORD 기록
ord-d3dd269bba1949b0b6018512e9dd6049
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07615562B2

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