1-Benzothiophene-3-sulfonyl chloride → HCID 21070416, 화합물

HRID 1435237

반응식

HRID 1435237 반응식
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])=[O:9])=[CH:6][N:5]=[C:4]([NH:19][CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[N:3]=1.[S:26]1[CH:30]=[C:29]([S:31](Cl)(=[O:33])=[O:32])[C:28]2[CH:35]=[CH:36][CH:37]=[CH:38][C:27]1=2>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])=[O:9])=[CH:6][N:5]=[C:4]([NH:19][CH:20]2[CH2:21][CH2:22][N:23]([S:31]([C:29]3[C:28]4[CH:35]=[CH:36][CH:37]=[CH:38][C:27]=4[S:26][CH:30]=3)(=[O:32])=[O:33])[CH2:24][CH2:25]2)[N:3]=1

참가 물질

3

반응물 2

HCID 27763401-Benzothiophene-3-sulfonyl chlorideHCID 9997668[4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone

생성물 1

HCID 21070416HCID 21070416, 화합물

실험 절차

The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone, Example 59, and benzo[b]thiophene-3-sulfonyl chloride (Maybridge) by the procedure described in Example 152. HR-MS (ES, m/z) calculated for C25H25FN5O4S2 [(M+H)+] 542.1327, observed 542.1331.

출처 및 근거

ORD 기록
ord-eb96601d6ccd4dc2a7f617c743ccb42d
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07615634B2

연결된 노트

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