Ammonia → (4-Amino-2-chloro-pyrimidin-5-yl)-[3-(tert-butyl-dimethyl-silanyloxy)-5,6-difluoro-2-methoxy-phenyl]-methanone
반응식
[NH3:1].[C:2]([Si:6]([CH3:29])([CH3:28])[O:7][C:8]1[C:9]([O:26][CH3:27])=[C:10]([C:16]([C:18]2[C:19](Cl)=[N:20][C:21]([Cl:24])=[N:22][CH:23]=2)=[O:17])[C:11]([F:15])=[C:12]([F:14])[CH:13]=1)([CH3:5])([CH3:4])[CH3:3]>C1(C)C=CC=CC=1>[NH2:1][C:19]1[C:18]([C:16]([C:10]2[C:11]([F:15])=[C:12]([F:14])[CH:13]=[C:8]([O:7][Si:6]([C:2]([CH3:3])([CH3:5])[CH3:4])([CH3:28])[CH3:29])[C:9]=2[O:26][CH3:27])=[O:17])=[CH:23][N:22]=[C:21]([Cl:24])[N:20]=1참가 물질
4
실험 절차
Ammonia gas was bubbled through a solution of [3-(tert-butyl-dimethyl-silanyloxy)-5,6-difluoro-2-methoxy-phenyl]-(2,4-dichloro-pyrimidin-5-yl)-methanone (900 mg, 2.003 mmol, Example 268) in toluene (10 mL) for about 30 minutes. The reaction mixture was concentrated to dryness to give (4-amino-2-chloro-pyrimidin-5-yl)-[3-(tert-butyl-dimethyl-silanyloxy)-5,6-difluoro-2-methoxy-phenyl]-methanone (1.02 g, yellow gum). The crude product was used without further purification.