[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → HCID 58777568, 화합물

반응식

[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[C:13]([O:17][CH3:18])=[CH:12][CH:11]=2)=[O:9])=[CH:6][N:5]=[C:4](S(CC)(=O)=O)[N:3]=1.FC(F)(F)C(O)=O.[CH3:31][S:32]([N:35]1[CH2:40][CH2:39][CH:38]([NH2:41])[CH2:37][CH2:36]1)(=[O:34])=[O:33]>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:11]=[CH:12][C:13]([O:17][CH3:18])=[C:14]([F:16])[CH:15]=2)=[O:9])=[CH:6][N:5]=[C:4]([NH:41][CH:38]2[CH2:39][CH2:40][N:35]([S:32]([CH3:31])(=[O:34])=[O:33])[CH2:36][CH2:37]2)[N:3]=1

참가 물질

반응물 2

HCID 11975076[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate

HCID 21070572HCID 21070572, 화합물

생성물 1

HCID 58777568HCID 58777568, 화합물

실험 절차

The same procedure as described in Example 90 was used starting with material from Example 372 and 1-methanesulfonyl-piperidin-4-ylamine; compound with trifluoroacetic acid (Example 162) to give [4-amino-2-(1-methanesulfonyl-piperidin-4-ylamino)-pyrimidin-5-yl]-(3-fluoro-4-methoxy-phenyl)-methanone as a white solid. MS (M+H)+: 424.

출처 및 근거

ORD 기록: ord-b38ff92561b846dba82f1f73e11664a6
출처 데이터셋: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07615634B2

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