2-Chlorobenzoyl chloride → HCID 178522372, 화합물

HRID 1435579노트

반응식

HRID 1435579 반응식
[C:1]1([C:7]2[NH:16][C:10]3=[N:11][CH:12]=[C:13]([NH2:15])[CH:14]=[C:9]3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20](Cl)=[O:21]>N1C=CC=CC=1>[Cl:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20]([NH:15][C:13]1[CH:14]=[C:9]2[N:8]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[NH:16][C:10]2=[N:11][CH:12]=1)=[O:21]

참가 물질

4

반응물 2

HCID 691102-Chlorobenzoyl chlorideHCID 178508009HCID 178508009, 화합물

생성물 1

HCID 178522372HCID 178522372, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

100 mg 2-phenyl-3H-imidazo[4,5-b]pyridin-6-ylamine (0.38 mmol,) in 4 ml dry pyridine were cooled to −40° C. and treated with 92 mg (1.1 equivalents) 2-chlorobenzoyl chloride. The cooling bath was removed an the mixture stirred for 1 hr at room temperature. The solvent was evaporated and the residue purified by chromatography on silica in methanol/dichloromethane mixtures. Yield 35 mg.

후처리

  1. customThe cooling bath was removed an the mixture
  2. customThe solvent was evaporated
  3. customthe residue purified by chromatography on silica in methanol/dichloromethane mixtures

출처 및 근거

ORD 기록
ord-41de7172583d403e8b0791d5a38c365f
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618964B2

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