4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl (2-{[(4-bromo-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

반응식

[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[C:16]([CH3:24])[CH:15]=1>>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:22])=[O:21])=[C:16]([CH3:24])[CH:15]=1

참가 물질

반응물 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

HCID 27813384-Bromo-2-methylbenzenesulfonyl chloride

생성물 1

HCID 10180344Ethyl (2-{[(4-bromo-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

실험 절차

The tide compound was prepared from ethyl 2-amino-4-thiazolylacetate and 4-bromo-2-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (48.2 mg) with purity >90%. MS (pos) m/z 419.2, 421.2.

출처 및 근거

ORD 기록: ord-4384a95fa3e840fc8958431e014dc3ca
출처 데이터셋: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07618961B2

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