4-Nitrophenyl chloroformate → HCID 69328481, 화합물

HRID 1435707노트

반응식

HRID 1435707 반응식
[C:1]([NH:5][C:6]([C:8]1[S:25][C:11]2[N:12]=[C:13]([S:23][CH3:24])[N:14]=[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[CH:17]=3)[C:10]=2[C:9]=1[NH2:26])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:28]([O:30][C:31]1[CH:36]=[CH:35][C:34]([N+:37]([O-:39])=[O:38])=[CH:33][CH:32]=1)=[O:29]>>[C:1]([NH:5][C:6]([C:8]1[S:25][C:11]2[N:12]=[C:13]([S:23][CH3:24])[N:14]=[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:28]([O:30][C:31]4[CH:32]=[CH:33][C:34]([N+:37]([O-:39])=[O:38])=[CH:35][CH:36]=4)=[O:29])[CH:17]=3)[C:10]=2[C:9]=1[NH2:26])=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 821294-Nitrophenyl chloroformateHCID 11531195HCID 11531195, 화합물

생성물 1

HCID 69328481HCID 69328481, 화합물

실험 절차

The reaction of tert-butyl 5-amino-2-methylthio-4-(3-hydroxyphenyl)-thieno[2,3-d]pyrimidine-6-carboxamide (example 1f, 400 mg) with p-nitro-phenyl chloroformate (207 mg) was performed according to the methods described in example 1 g. Evaporation of the solvent under reduced pressure yielded the crude title compound.

후처리

  1. customEvaporation of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-3d7e93ab4266451b944e77ec7b468c31
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618963B2

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