Ethyl (2E)-(1-isopropenyl-6,7-dihydro-8H-pyrido[3,4-b]pyrrolizin-8-ylidene)ethanoate → ethyl (1-isopropyl-7,8-dihydro-6H-pyrido[3,4-b]pyrrolizin-8-yl)acetate

HRID 1435896노트

반응식

HRID 1435896 반응식
[C:1]([C:4]1[C:9]2[CH:10]=[C:11]3[N:15]([C:8]=2[CH:7]=[CH:6][N:5]=1)[CH2:14][CH2:13]/[C:12]/3=[CH:16]\[C:17]([O:19][CH2:20][CH3:21])=[O:18])([CH3:3])=[CH2:2]>CO.[OH-].[OH-].[Pd+2]>[CH:1]([C:4]1[C:9]2[CH:10]=[C:11]3[N:15]([C:8]=2[CH:7]=[CH:6][N:5]=1)[CH2:14][CH2:13][CH:12]3[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])([CH3:3])[CH3:2]

참가 물질

4

반응물 1

HCID 86601999Ethyl (2E)-(1-isopropenyl-6,7-dihydro-8H-pyrido[3,4-b]pyrrolizin-8-ylidene)ethanoate

생성물 1

HCID 86601998ethyl (1-isopropyl-7,8-dihydro-6H-pyrido[3,4-b]pyrrolizin-8-yl)acetate

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

To a solution of ethyl (2E)-(1-isopropenyl-6,7-dihydro-8H-pyrido[3,4-b]-pyrrolizin-8-ylidene)ethanoate (0.40 g, 1.4 mmol) in MeOH (20 mL) was added Pd(OH)2 (0.20 g). The mixture was stirred under 1 atm of H2 for 3 h. The mixture was filtered over celite and evaporated to provide the title compound.

후처리

  1. filtrationThe mixture was filtered over celite
  2. customevaporated

출처 및 근거

ORD 기록
ord-295186993de54c8c91545ddb5ca82534
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618979B2

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