Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-Amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2,2-Dimethoxypropane | HCID 6495 | — |
| 반응물 | (S)-2-Amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-di hydro-pyridazin-4-yl)-phenyl]-propionic acid | HCID 11536782 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-Amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid methyl ester | HCID 69077803 | — |
반응 단계
2-(S)-Amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid (0.40 g, 1.0 mmol) was dissolved in MeOH (2.6 mL). Dimethoxypropane (0.26 mL) and 1N HCl in dioxane (0.33 mL) were added and stirred at room temperature for 24 h. The mixture was concentrated in vacuo to give 2-Amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid methyl ester. MS (ES+) 318.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07618983B2 |
| 출처 데이터셋 | uspto-grants-2009_11 |
| ORD ID | ord-fefe75b7ab6e4f26b6cf7267ccd86610 |
| 출처 메모 | uspto-grants-2009_11 |