C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([O:14][C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[C:21]([NH2:25])=[N:20][CH:19]=[CH:18]3)[CH2:9]1)=O)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[NH3:8].[NH:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([O:14][C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[C:21]([NH2:25])=[N:20][CH:19]=[CH:18]3)[CH2:9]1A mixture of (S)-3-(1-amino-isoquinolin-6-yloxy)piperidin-1-carboxylic acid tert-butyl ester (72 mg) in dichloromethane (2 ml) and trifluoroacetic acid (1 ml) was stirred at ambient temperature for 1.5 h. The mixture was concentrated in vacuo then flash chromatography of the residue (eluent: 2-10% methanol in dichloromethane with 1% aqueous ammonia) gave (S)-6-(piperidin-3-yloxy)-isoquinolin-1-ylamine, El-MS: m/z=244.4 [M+H]+.
불러오는 중…