Methanol → HCID 68878024, 화합물

HRID 1436011

반응식

HRID 1436011 반응식
[Cl:1]C1C=CC=C(C(OO)=[O:9])C=1.[Br:12][C:13]1[C:22]([O:23][CH3:24])=[CH:21][CH:20]=[C:19]2[C:14]=1[CH:15]=[CH:16][N:17]=[CH:18]2.CO>ClCCl>[ClH:1].[Br:12][C:13]1[C:22]([O:23][CH3:24])=[CH:21][CH:20]=[C:19]2[C:14]=1[CH:15]=[CH:16][N+:17]([O-:9])=[CH:18]2

참가 물질

5

반응물 3

HCID 887MethanolHCID 70297m-Chloroperbenzoic acidHCID 222265455-Bromo-6-methoxy-isoquinoline

생성물 1

HCID 68878024HCID 68878024, 화합물수율 83.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

m-Chloroperbenzoic acid (1.4 g, 75%) was added in portions to a stirred solution of 5-bromo-6-methoxyisoquinoline (12 g, 5.04 mmol) in dichloromethane (12 ml). The mixture was stirred for 1 h then further dichloromethane (10 ml) added and the mixture stirred for an additional 2 h. Methanol (12 ml) was added and the mixture concentrated in vacuo to ˜9 ml, then 1M hydrochloric acid in diethyl ether (10 ml) was added. The mixture was diluted with ether and filtered, the precipitated solid was washed with diethyl ether and dried in vacuo to give crude 5-bromo-6-methoxyisoquinoline-N-oxide hydrochloride (1.22 g).

후처리

  1. stirringthe mixture stirred for an additional 2 h
  2. concentrationthe mixture concentrated in vacuo to ˜9 ml
  3. addition1M hydrochloric acid in diethyl ether (10 ml) was added
  4. additionThe mixture was diluted with ether
  5. filtrationfiltered
  6. washthe precipitated solid was washed with diethyl ether
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-a3cddaab01a94e84accae8268c62de9f
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618985B2

연결된 노트

불러오는 중…