Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Boc-amino)piperidine → Hydrochloric Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Boc-amino)piperidine | HCID 4233041 | — |
| 반응물 | 4-Chloroisoquinoline-5-sulfonyl chloride | HCID 22121908 | — |
| 생성물 | Hydrochloric Acid | HCID 313 | 1,932.7% |
| 생성물 | 3-(Tert-butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67242669 | — |
| 생성물 | (r/s)-3-Amino-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67242690 | — |
반응 단계
(R/S)-3-(tert-Butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)-piperidine (Intermediate 18) is prepared from 4-chloro-5-isoquinolinesulfonyl chloride (183 mg) and 3-(tert-butoxycarbonylamino)piperidine (168 mg) according to the method described in Example 1, Step A, and then used in the method of Example 1, Step B in a similar manner to obtain the title compound as hydrochloride (164 mg (predictive yield)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07618984B2 |
| 출처 데이터셋 | uspto-grants-2009_11 |
| ORD ID | ord-126c299982984ca3a1f4790663298875 |
| 출처 메모 | uspto-grants-2009_11 |