Phosphine, triphenyl-, hydrobromide → [(6R*,9aS*)-6-(4-fluorophenyl)-4-oxooctahydropyrido[2,1-c][1,4]oxazin-3-yl]triphenylphosphonium bromide

HRID 1436092노트

반응식

HRID 1436092 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[N:17]3[C@H:12]([CH2:13][O:14][CH:15](O)[C:16]3=[O:18])[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[Br-:20].[C:21]1([PH+:27]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(#N)C>[Br-:20].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[N:17]3[C@H:12]([CH2:13][O:14][CH:15]([P+:27]([C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)[C:16]3=[O:18])[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 517696Phosphine, triphenyl-, hydrobromideHCID 69010340(6R*,9aS*)-6-(4-fluorophenyl)-3-hydroxyhexahydropyrido[2,1-c][1,4]oxazin-4-one

생성물 1

HCID 86612604[(6R*,9aS*)-6-(4-fluorophenyl)-4-oxooctahydropyrido[2,1-c][1,4]oxazin-3-yl]triphenylphosphonium bromide수율 98.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of (6R*,9aS*)-6-(4-fluorophenyl)-3-hydroxyhexahydropyrido[2,1-c][1,4]oxazin-4-one (26 mg) and triphenylphosphonium bromide (40 mg) in acetonitrile (3 mL) was heated under reflux for one hour and 30 minutes. The reaction solution was left to cool to room temperature, and then the solvent was evaporated under reduced pressure to obtain 57 mg of the title compound. The property value of the compound is as follows.

후처리

  1. temperatureunder reflux for one hour and 30 minutes
  2. waitThe reaction solution was left
  3. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-f5dafab9d2304369a11a48200c245442
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618960B2

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