4-Chloro-2-methylquinazoline → N-(5-Methoxypyrazin-2-yl)-N,2-dimethylquinazolin-4-amine

반응식

[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=[C:12]([CH3:20])[N:11]=2)=[N:7][CH:8]=1.N[C:22]1C=NC(OC)=CN=1.ClC1C2C(=CC=CC=2)N=C(C)N=1>>[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([N:9]([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=[C:12]([CH3:20])[N:11]=2)[CH3:22])=[N:7][CH:8]=1

참가 물질

반응물 3

HCID 27854214-Chloro-2-methylquinazoline

HCID 145364295-Methoxypyrazin-2-amine

HCID 42625839N-(5-Methoxypyrazin-2-yl)-2-methylquinazolin-4-amine

생성물 1

HCID 42625913N-(5-Methoxypyrazin-2-yl)-N,2-dimethylquinazolin-4-amine

실험 절차

(5-Methoxy-pyrazin-2-yl)-(2-methyl-quinazolin-4-yl)-amine: The title compound was prepared from 2-amino-5-methoxy-pyrazine (105 mg, 0.84 mmol) and 4-chloro-2-methyl-quinazoline (150 mg, 0.84 mmol) by a procedure similar to example 125c, yielding 106 mg of the title product.

출처 및 근거

ORD 기록: ord-79b68bf820fd4f8cb405e008a125a3e6
출처 데이터셋: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07618975B2

반응 노트

불러오는 중…