4-(Methylamino)pyridine → N,2-Dimethyl-N-(pyridin-4-yl)quinazolin-4-amine

HRID 1436304

반응식

HRID 1436304 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[N:3]=1.[N:13]1[CH:18]=[CH:17][C:16]([NH:19][CH3:20])=[CH:15][CH:14]=1>>[CH3:12][C:4]1[N:3]=[C:2]([N:19]([C:16]2[CH:17]=[CH:18][N:13]=[CH:14][CH:15]=2)[CH3:20])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1

참가 물질

3

반응물 2

HCID 1230984-(Methylamino)pyridineHCID 27854214-Chloro-2-methylquinazoline

생성물 1

HCID 57938814N,2-Dimethyl-N-(pyridin-4-yl)quinazolin-4-amine

실험 절차

The title compound was prepared from 4-chloro-2-methyl-quinazoline (0.178 g, 2.13 mmol) and (pyridin-4-yl)-methyl-amine (0.108 g, 1.84 mmol) by a procedure similar to examples 125c (0.224 g, 49%). 1H NMR (CDCl3): 8.39 (m, 2H), 7.91 (d, J=8.4, 1H), 7.73 (ddd, J=1.2, 6.6, 8.4, 1H), 7.41 (m, 1H), 7.23-7.29 (m, 1H), 6.79-6.82 (m, 2H), 3.70 (s, 3H), 2.83 (s, 3H).

출처 및 근거

ORD 기록
ord-8d916c0bc6f0476f9c749fdac790874d
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618975B2

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