Ethanol → N-(4-methoxyphenyl)-N,2-dimethylpteridin-4-amine

HRID 1436307

반응식

HRID 1436307 반응식
Cl[C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=[C:4]([CH3:12])[N:3]=1.Cl[C:14]1N=[C:18](C)[N:17]=[C:16](N)[C:15]=1N.O1[CH2:28][CH2:27][O:26][CH:25](O)C1O.[CH2:31](O)C>>[CH3:25][O:26][C:27]1[CH:14]=[CH:15][C:16]([N:17]([C:2]2[C:11]3[C:6](=[N:7][CH:8]=[CH:9][N:10]=3)[N:5]=[C:4]([CH3:12])[N:3]=2)[CH3:18])=[CH:31][CH:28]=1

참가 물질

5

반응물 4

HCID 702EthanolHCID 961701,4-Dioxane-2,3-diolHCID 5941456-Chloro-2-methylpyrimidine-4,5-diamineHCID 228937924-Chloro-2-methylpteridine

생성물 1

HCID 46883988N-(4-methoxyphenyl)-N,2-dimethylpteridin-4-amine수율 97%

실험 절차

4-Chloro-2-methyl-pteridine. A mixture of 6-chloro-2-methyl-pyrimidine-4,5-diamine (37 mg, 0.233 mmol) and 1,4-dioxane-2,3-diol (32 mg, 0.266 mmol) in 0.8 mL of absolute ethanol was stirred at room temperature for 2 h. The reaction mixture was evaporated to dryness and the residue was purified by column chromatography (50% ethyl acetate/hexane) to give the title compound (41 mg, 0.227 mmol, 97%). 1H NMR (CDCl3): 9.24 (d, J=1.8, 1H), 9.05 (d, J=1.5, 1H), 2.99 (s, 3H).

후처리

  1. customThe reaction mixture was evaporated to dryness
  2. customthe residue was purified by column chromatography (50% ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-3a2818827ce64f1a9dba807c5a7c6b5f
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618975B2

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