Isothiocyanatopotassium → 1-(4-Chloro-3-fluoro-phenyl)-2-thiocyanato-ethanone
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Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([F:12])[CH:6]=1)=[O:4].[N-:13]=[C:14]=[S:15].[K+]>C(O)C>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][S:15][C:14]#[N:13])=[CH:6][C:7]=1[F:12]참가 물질
4
실험 절차
In the same manner as described in step 4 of Example 78, using 2-bromo-1-(4-chloro-3-fluoro-phenyl)-ethanone (2.7 g, 10.7 mmol), prepared in the previous step, and potassium isothiocyanate (1.25 g, 12.8 mmol) in ethanol (150 mL) the crude product was collected by suction filtration to give 1-(4-chloro-3-fluoro-phenyl)-2-thiocyanato-ethanone (2.47 g, 100%), which was used in the next step without further purification. MS (ES) m/z 230[M+H+].
후처리
- filtrationwas collected by suction filtration
출처 및 근거
- ORD 기록
- ord-7e06f8fe6fc743dfb43f3131c67df4b5
- 출처 데이터셋
- uspto-grants-2009_11
- 특허 번호
- US07618990B2
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