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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Trifluoroacetic acid → 2-(S)-Amino-3-(3,5-difluorophenyl)-propan-1-ol trifluoroacetate

HRID 1436478
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인쇄 미리보기

반응식

HRID 1436478 반응식
C(OC(=O)[NH:7][C@H:8]([CH2:18][OH:19])[CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[CH:11]=1)(C)(C)C.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>ClCCl>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[NH2:7][C@@H:8]([CH2:9][C:10]1[CH:11]=[C:12]([F:17])[CH:13]=[C:14]([F:16])[CH:15]=1)[CH2:18][OH:19]
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참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 57881012(S)-2-Boc-amino-3-(3,5-difluorophenyl)propan-1-OL

생성물 1

HCID 690152702-(S)-Amino-3-(3,5-difluorophenyl)-propan-1-ol trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Dissolve [2-(3,5-difluorophenyl)-1-(S)-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester (4.57 g, 15.9 mmol) in dichloromethane (20 mL). Add trifluoroacetic acid (20 mL) and stir 45 min and concentrate to give the title compound as a thick residue.

후처리

  1. concentrationconcentrate

출처 및 근거

ORD 기록
ord-9085fae18ef84c4bac9be173f4e75943
출처 데이터셋
uspto-grants-2009_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07618978B2

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