2-(Dibenzylamino)-3-(3,5-difluorophenyl)-propanal → 2-(S)-[2-(S)-Amino-3-(3,5-difluoro-phenyl)-1-(S)-hydroxy-propyl]-4-[2-(3-methyl-butyl)-phenyl]-3-oxo-piperazine-1-carboxylic acid tert-butyl ester

HRID 1436521노트

반응식

HRID 1436521 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][CH2:21][CH:22]([CH3:24])[CH3:23])[C:10](=[O:25])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C([N:33](CC1C=CC=CC=1)[CH:34]([CH2:37][C:38]1[CH:43]=[C:42]([F:44])[CH:41]=[C:40]([F:45])[CH:39]=1)[CH:35]=[O:36])C1C=CC=CC=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][CH2:21][CH:22]([CH3:23])[CH3:24])[C:10](=[O:25])[C@@H:9]1[C@@H:35]([OH:36])[C@@H:34]([NH2:33])[CH2:37][C:38]1[CH:39]=[C:40]([F:45])[CH:41]=[C:42]([F:44])[CH:43]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 586224332-(Dibenzylamino)-3-(3,5-difluorophenyl)-propanalHCID 690176154-[2-(3-Methyl-butyl)-phenyl]-3-oxo-piperazine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 690159102-(S)-[2-(S)-Amino-3-(3,5-difluoro-phenyl)-1-(S)-hydroxy-propyl]-4-[2-(3-methyl-butyl)-phenyl]-3-oxo-piperazine-1-carboxylic acid tert-butyl ester

실험 절차

The title is prepared by reacting 4-[2-(3-methyl-butyl)-phenyl]-3-oxo-piperazine-1-carboxylic acid tert-butyl ester with 2-(dibenzylamino)-3-(3,5-difluorophenyl)-propanal essentially as described in Preparation 41.

후처리

  1. customThe title is prepared
  2. customas described in Preparation 41

출처 및 근거

ORD 기록
ord-1a3a372096624bfaa657a10174cfa929
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618978B2

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