Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 3-Bromo-5-(methoxycarbonyl)benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 5-Bromoisophthalic acid | HCID 90073 | — |
| 반응물 | 1,3-Benzenedicarboxylic acid, 5-bromo-, 1,3-dimethyl ester | HCID 103954 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-Bromo-5-(methoxycarbonyl)benzoic acid | HCID 22593641 | — |
반응 단계
Add a solution of NaOH pellets (3.66 g, 91.5 mmol) in methanol (200 mL) to dimethyl-5-bromoisophthalate (25 g) and stir the resulting solution overnight at room temperature. Add water (300 mL) and extract with dichloromethane (3×200 mL). Acidify the aqueous with 5 N HCl (20 mL), filter the precipitate and dry to give a mixture of the title compound and 5-bromo-isophthalic acid in about a 6:4 ratio by LCMS (18.2 g crude).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07618978B2 |
| 출처 데이터셋 | uspto-grants-2009_11 |
| ORD ID | ord-40960b307c61456d9b46c0fd87310bf3 |
| 출처 메모 | uspto-grants-2009_11 |