Pyrazole → 2-(1H-Pyrazol-1-yl)quinolin-8-ol

반응식

Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([OH:12])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH:13]1[CH:17]=[CH:16][CH:15]=[N:14]1>>[N:13]1([C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[C:5]([OH:12])[CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH:17]=[CH:16][CH:15]=[N:14]1

참가 물질

반응물 2

HCID 1048Pyrazole

HCID 2748782-Chloroquinolin-8-ol

생성물 1

HCID 579393522-(1H-Pyrazol-1-yl)quinolin-8-ol

실험 절차

A mixture of 2-chloro-quinolin-8-ol 3 (80 mg, 0.447 mmol) and pyrazole (152 mg, 2.233 mmol) was heated at 175° C. in a steel autoclave for 48 h. The crude product was then purified by column chromatography on silica (ethyl acetate/hexane, 1:1) to give 2-pyrazol-1-yl-quinolin-8-ol (compound ID 964) I1 as a white solid (68 mg, 72%).

후처리

customThe crude product was then purified by column chromatography on silica (ethyl acetate/hexane, 1:1)

출처 및 근거

ORD 기록: ord-f27adee2d4684c83829641633d37874e
출처 데이터셋: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07619091B2

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