Ethyl trifluoroacetate → 2,2,2-trifluoro-N-(morpholin-2-ylmethyl)acetamide

HRID 1437135노트

반응식

HRID 1437135 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][NH2:8])[CH2:2]1.C([O:11][C:12](=O)[C:13]([F:16])([F:15])[F:14])C>CO>[F:14][C:13]([F:16])([F:15])[C:12]([NH:8][CH2:7][CH:3]1[O:4][CH2:5][CH2:6][NH:1][CH2:2]1)=[O:11]

참가 물질

4

반응물 2

HCID 9794Ethyl trifluoroacetateHCID 45420271-(Morpholin-2-yl)methanamine

생성물 1

HCID 115502612,2,2-trifluoro-N-(morpholin-2-ylmethyl)acetamide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
22 °C

실험 절차

To a stirred solution of morpholin-2-ylmethylamine (3.1 g) in methanol (70 ml) under nitrogen was added an ethereal solution of ethyl-α,α,α-trifluoroacetate (5 ml in 20 ml ether) which had been washed with saturated aqueous sodium bicarbonate, water and brine, and dried. The mixture was stirred for 30 min at 22° C. before removal of all volatiles in vacuo. The residue was dissolved in methanol (10 ml) and the volatiles again removed in vacuo to give the title compound as a white crunchy foam (4.9 g).

후처리

  1. washhad been washed with saturated aqueous sodium bicarbonate, water and brine
  2. customdried
  3. dissolutionThe residue was dissolved in methanol (10 ml)
  4. customthe volatiles again removed in vacuo

출처 및 근거

ORD 기록
ord-808439c25fed419abb82d13340e1e9fd
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07622464B2

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