Triethylamine → (S)-Methyl morpholine-3-carboxylate

HRID 1437276노트

반응식

HRID 1437276 반응식
C(N(CC)CC)C.[CH3:8][O:9][C:10](=[O:18])[C@@H:11]([NH2:17])[CH2:12][O:13][CH2:14][CH2:15]Cl>CO>[CH3:8][O:9][C:10]([C@@H:11]1[CH2:12][O:13][CH2:14][CH2:15][NH:17]1)=[O:18]

참가 물질

4

반응물 2

HCID 8471TriethylamineHCID 86605437HCID 86605437, 화합물

생성물 1

HCID 6558896(S)-Methyl morpholine-3-carboxylate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Triethylamine (1.2 mL) was added to the above-obtained (2S)-2-amino-3-(2-chloroethoxy)propanoic acid methyl ester (726 mg) in methanol (10 mL), and the resultant mixture was refluxed under heat for 3 hours, and then cooled in air. The reaction solvent was removed under reduced pressure. Ethyl acetate was added to the residue, and insoluble matter was removed by filtration. The solvent of the filtrate was removed under reduced pressure, to thereby give the title compound as an oily product (467 mg, 80%).

후처리

  1. temperatureunder heat for 3 hours
  2. temperaturecooled in air
  3. customThe reaction solvent was removed under reduced pressure
  4. additionEthyl acetate was added to the residue, and insoluble matter
  5. customwas removed by filtration
  6. customThe solvent of the filtrate was removed under reduced pressure

출처 및 근거

ORD 기록
ord-1e69003d772f40dcaa0000907fd03886
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07622471B2

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