(3,4-Dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methanol → 3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehyde

HRID 1437329노트

반응식

HRID 1437329 반응식
[S:1]1[CH2:6][CH2:5][NH:4][C:3]2[N:7]=[C:8]([CH2:11][OH:12])[CH:9]=[CH:10][C:2]1=2>ClCCl.[O-2].[O-2].[Mn+4]>[S:1]1[CH2:6][CH2:5][NH:4][C:3]2[N:7]=[C:8]([CH:11]=[O:12])[CH:9]=[CH:10][C:2]1=2

참가 물질

4

반응물 1

HCID 18454501(3,4-Dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methanol

생성물 1

HCID 184545003,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehyde수율 50.3%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

The alcohol (a) (0.482 g) in dry dichloromethane (50 ml) was stirred with manganese dioxide (1.2 g) for 18 hours and the mixture was filtered. The filtrate was evaporated and chomatographed on silica gel, eluting with methanol-dichloromethane (1:50) to afford a yellow solid (0.24 g).

후처리

  1. filtrationthe mixture was filtered
  2. customThe filtrate was evaporated
  3. washeluting with methanol-dichloromethane (1:50)

출처 및 근거

ORD 기록
ord-e0ff8619783e438fb1a37a91f64277fb
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07622481B2

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