Cesium fluoride → 3-Methoxyquinoxalin-5-ol
반응식
[CH3:1][O:2][C:3]1[CH:12]=[N:11][C:10]2[C:5](=[C:6]([O:13][Si](C(C)C)(C(C)C)C(C)C)[CH:7]=[CH:8][CH:9]=2)[N:4]=1.[F-].[Cs+]>O1CCCC1.CO>[CH3:1][O:2][C:3]1[CH:12]=[N:11][C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([OH:13])[C:5]=2[N:4]=1참가 물질
4
실험 절차
A solution of (d) (6.95 g, 21 mmol) in tetrahydrofuran/methanol (280 ml/140 ml) was treated with caesium fluoride (4.73 g, 31.4 mmol) and stirred for 18 hours. The mixture was evaporated and the residue partitioned between diethyl ether and dilute aqueous hydrochloric acid. The aqueous phase was further extracted with diethyl ether and the combined extracts dried and evaporated to give an oil (4.2 g).
후처리
- customThe mixture was evaporated
- customthe residue partitioned between diethyl ether and dilute aqueous hydrochloric acid
- extractionThe aqueous phase was further extracted with diethyl ether
- customthe combined extracts dried
- customevaporated
출처 및 근거
- ORD 기록
- ord-e352872d5e004c98b4fdadc92c7b0840
- 출처 데이터셋
- uspto-grants-2009_11
- 특허 번호
- US07622481B2
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