1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → 4-Hydroxyquinoline-6-carbonitrile

HRID 1437387노트

반응식

HRID 1437387 반응식
CC1(C)O[C:6](=[O:8])[C:5](=[CH:9][NH:10][C:11]2[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=2)C(=O)O1.C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>CCOCC>[O:8]=[C:6]1[C:12]2[C:11](=[CH:18][CH:17]=[C:14]([C:15]#[N:16])[CH:13]=2)[NH:10][CH:9]=[CH:5]1

참가 물질

4

반응물 2

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)HCID 116947054-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile

생성물 1

HCID 116583514-Hydroxyquinoline-6-carbonitrile수율 94.3%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Benzonitrile (a) (27.5 g) was added portionwise over 5 minutes to refluxing Dowtherm A (200 ml). After refluxing an additional 5 minutes, the mixture was allowed to cool to room temperature and diluted with ether (200 ml) with stirring. The product was filtered off, washed thoroughly with ether and air dried to provide a gold solid (16.2 g, 94%).

후처리

  1. temperatureAfter refluxing an additional 5 minutes
  2. filtrationThe product was filtered off
  3. washwashed thoroughly with ether and air
  4. customdried

출처 및 근거

ORD 기록
ord-3be0c4741a29485f881d876f25db75a7
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07622481B2

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