2,5-Dimethoxybenzyl alcohol → cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-1-(2,5-dimethoxybenzyl)-3-phenylpiperidine

HRID 1437642노트

반응식

HRID 1437642 반응식
Cl.[F:2][C:3]([F:29])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][NH:12][CH2:11][C@H:10]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH3:30][O:31][C:32]1[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][C:33]=1[CH2:34]O>>[F:29][C:3]([F:2])([F:28])[C:4]1[CH:5]=[C:6]([CH:21]=[C:22]([C:24]([F:27])([F:25])[F:26])[CH:23]=1)[CH2:7][O:8][C@H:9]1[CH2:14][CH2:13][N:12]([CH2:34][C:33]2[CH:36]=[C:37]([O:40][CH3:41])[CH:38]=[CH:39][C:32]=2[O:31][CH3:30])[CH2:11][C@H:10]1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

참가 물질

3

반응물 2

HCID 1184952,5-Dimethoxybenzyl alcoholHCID 86606807cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidine hydrochloride

생성물 1

HCID 86606820cis-4-[[3,5-Bis(trifluoromethyl)benzyl]oxy]-1-(2,5-dimethoxybenzyl)-3-phenylpiperidine수율 23.8%

실험 절차

The compound (0.20 g) obtained in Example 1 and 2,5-dimethoxybenzyl alcohol (0.12 g) were reacted and treated in the same manner as in the method described in Example 16 to obtain the title compound as colorless oil (0.060 g, 23%).

후처리

  1. additiontreated in the same manner as in the method

출처 및 근거

ORD 기록
ord-e54581387f2a4aa19380b4d168e09077
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07622487B2

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