Dimethylcarbamoyl Chloride → Urea, N,N-dimethyl-N-2-propynyl- (9CI)

HRID 1437808노트

반응식

HRID 1437808 반응식
[CH3:1][N:2]([CH3:6])[C:3](Cl)=[O:4].[CH2:7]([NH2:10])[C:8]#[CH:9].CN(C1C=CC=CN=1)C>N1C=CC=CC=1.C(OCC)(=O)C>[CH3:1][N:2]([CH3:6])[C:3]([NH:10][CH2:7][C:8]#[CH:9])=[O:4]

참가 물질

6

반응물 3

HCID 6598Dimethylcarbamoyl ChlorideHCID 218852-DimethylaminopyridineHCID 239041Propargylamine

생성물 1

HCID 44190381Urea, N,N-dimethyl-N-2-propynyl- (9CI)

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 8857Ethyl Acetate용매

실험 절차

Dimethyl carbamylchloride (0.84 mL, 9.1 mmol) was added to a stirred solution of propargylamine (0.62 mL, 9.1 mmol) and dimethylaminopyridine (22 mg, 0.18 mmol) in pyridine (5 mL) at room temperature. The resulting suspension was stirred at ambient temperature for approximately 15 h. The reaction mixture was diluted with ethyl acetate and washed successively with 1N HCl and brine. The organic phase was dried (Na2SO4), filtered and concentrated in vacuo to afford the title compound (i-3), which was used without further purification.

후처리

  1. washwashed successively with 1N HCl and brine
  2. dry with materialThe organic phase was dried (Na2SO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-52bfc46730a14e8685bac33106678b71
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07622449B2

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