Potassium Cyanide → 2,4-Difluoro-α-hydroxy-5-methoxybenzeneacetonitrile

HRID 1438149노트

반응식

HRID 1438149 반응식
[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([O:11][CH3:12])=[CH:6][C:3]=1[CH:4]=[O:5].[C-:13]#[N:14].[K+].OS([O-])=O.[Na+]>C(OCC)(=O)C.O>[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([O:11][CH3:12])=[CH:6][C:3]=1[CH:4]([OH:5])[C:13]#[N:14]

참가 물질

6

반응물 3

HCID 9032Potassium CyanideHCID 23665763Sodium BisulfiteHCID 578038672,4-Difluoro-5-methoxybenzaldehyde

생성물 1

HCID 579429112,4-Difluoro-α-hydroxy-5-methoxybenzeneacetonitrile

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

To 98A (506 mg, 2.94 mmol) in ethyl acetate (10 mL) was added a solution of KCN (574 mg, 8.82 mmol) and NaHSO3 (917 mg, 8.82 mmol) dissolved in H2O (10 mL). The reaction was stirred at rt for 48 h. It was extracted with ethyl acetate (2×50 mL). The combined organic extracts were dried and concentrated to give 98B as an oil. It was used for next step without purification.

후처리

  1. extractionIt was extracted with ethyl acetate (2×50 mL)
  2. customThe combined organic extracts were dried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d12308c8358c46069e65ba7d4d129058
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07622585B2

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